Epigenetic and Transcriptomic Regulation of Lung Repair during Recovery from Influenza Infection.

ABSTRACT: Seasonal and pandemic influenza is a cause of morbidity and mortality worldwide. Most people infected with influenza virus display mild-to-moderate disease phenotypes and recover within a few weeks. Influenza is known to cause persistent alveolitis in animal models; however, little is known about the molecular pathways involved in this phenotype. We challenged C57BL/6 mice with influenza A/PR/8/34 and examined lung pathologic processes and inflammation, as well as transcriptomic and epigenetic changes at 21 to 60 days after infection. Influenza induced persistent parenchymal lung inflammation, alveolar epithelial metaplasia, and epithelial endoplasmic reticulum stress that were evident after the clearance of virus and resolution of morbidity. Influenza infection induced robust changes in t

SUBMITTER: Pociask DA 

PROVIDER: S-EPMC5397680 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature