Subventricular zones: new key targets for glioblastoma treatment.

ABSTRACT:

Background

We aimed to identify subventricular zone (SVZ)-related prognostic factors of survival and patterns of recurrence among patients with glioblastoma.

Methods

Forty-three patients with primary diagnosed glioblastoma treated in our Cancer Center between 2006 and 2010 were identified. All patients received surgical resection, followed by temozolomide-based chemoradiation. Ipsilateral (iSVZ), contralateral (cSVZ) and bilateral (bSVZ) SVZs were retrospectively segmented and radiation dose-volume histograms were generated. Multivariate analysis using the Cox proportional hazards model was assessed to examine the relationship between prognostic factors and time to progression (TTP) or overall survival (OS).

Results

Median age was 59 years (range: 25-85). Median follo

SUBMITTER: Khalifa J 

PROVIDER: S-EPMC5397708 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature