Sex differences in insular cortex gyri responses to a brief static handgrip challenge.

ABSTRACT:

Background

Cardiovascular disease varies between sexes, suggesting male-female autonomic control differences. Insular gyri help coordinate autonomic regulation and show a sex-dependent response to a sympathetic challenge.

Methods

We examined sex-related insular gyral responses to a short static handgrip exercise challenge eliciting parasympathetic withdrawal with functional magnetic resonance imaging (fMRI) during four 16-s challenges (80% maximum strength) in 23 healthy females (age; mean ± std 50 ± 8 years) and 40 males (46 ± 9 years). Heart rate (HR) and fMRI signals were compared with repeated measures ANOVA (P < 0.05). Additional analyses were performed with age and age interactions, as well as right-handed only subjects.

Results

Females showed higher rest

SUBMITTER: Macey PM 

PROVIDER: S-EPMC5397762 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature