Estimating the irreversible pressure drop across a stenosis by quantifying turbulence production using 4D Flow MRI.

ABSTRACT: The pressure drop across a stenotic vessel is an important parameter in medicine, providing a commonly used and intuitive metric for evaluating the severity of the stenosis. However, non-invasive estimation of the pressure drop under pathological conditions has remained difficult. This study demonstrates a novel method to quantify the irreversible pressure drop across a stenosis using 4D Flow MRI by calculating the total turbulence production of the flow. Simulation MRI acquisitions showed that the energy lost to turbulence production can be accurately quantified with 4D Flow MRI within a range of practical spatial resolutions (1-3 mm; regression slope = 0.91, R² = 0.96). The quantification of the turbulence production was not substantially influenced by the signal-to-noise rati

SUBMITTER: Ha H 

PROVIDER: S-EPMC5397859 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature