Hyperpolarized ¹³C Spectroscopic Evaluation of Oxidative Stress in a Rodent Model of Steatohepatitis.

ABSTRACT: Nonalcoholic fatty liver disease (NAFLD) has become highly prevalent, now considered the most common liver disease in the western world. Approximately one-third of patients with NASH develop non-alchoholic steatohepatitis (NASH), histologically defined by lobular and portal inflammation, and accompanied by marked oxidative stress. Patients with NASH are at increased risk for cirrhosis and hepatocellular carcinoma, and diagnosis currently requires invasive biopsy. In animal models of NASH, particularly the methionine-choline deficient (MCD) model, profound changes are seen in redox enzymes and key intracellular antioxidants. To study antioxidant status in NASH non-invasively, we applied the redox probe hyperpolarized [1-¹³C] dehydroascorbic acid (HP DHA), which is reduced to Vita

SUBMITTER: Wilson DM 

PROVIDER: S-EPMC5397869 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature