Synthesis of side-chain oxysterols and their enantiomers through cross-metathesis reactions of Δ²² steroids.

ABSTRACT: A synthetic route that utilizes a cross-metathesis reaction with Δ²² steroids has been developed to prepare sterols with varying C-27 side-chains. Natural sterols containing hydroxyl groups at the 25 and (25R)-26 positions were prepared. Enantiomers of cholesterol and (3β,25R)-26-hydroxycholesterol (27-hydroxycholesterol) trideuterated at C-19 were prepared for future biological studies.

SUBMITTER: Brownholland DP 

PROVIDER: S-EPMC5398201 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature