Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples.

ABSTRACT: The fight against cancer is hindered by its highly heterogeneous nature. Genome-wide sequencing studies have shown that individual malignancies contain many mutations that range from those commonly found in tumor genomes to rare somatic variants present only in a small fraction of lesions. Such rare somatic variants dominate the landscape of genomic mutations in cancer, yet efforts to correlate somatic mutations found in one or few individuals with functional roles have been largely unsuccessful. Traditional methods for identifying somatic variants that drive cancer are 'gene-centric' in that they consider only somatic variants within a particular gene and make no comparison to other similar genes in the same family that may play a similar role in cancer. In this work, we present oncodomai

SUBMITTER: Peterson TA 

PROVIDER: S-EPMC5398485 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature