Lymph node volume predicts survival but not nodal clearance in Stage IIIA-IIIB NSCLC.

ABSTRACT:

Background

Locally advanced non-small cell lung cancer (LA-NSCLC) patients have poorer survival and local control with mediastinal node (N2) tumor involvement at resection. Earlier assessment of nodal burden could inform clinical decision-making prior to surgery. This study evaluated the association between clinical outcomes and lymph node volume before and after neoadjuvant therapy.

Materials and methods

CT imaging of patients with operable LA-NSCLC treated with chemoradiation and surgical resection was assessed. Clinically involved lymph node stations were identified by FDG-PET or mediastinoscopy. Locoregional recurrence (LRR), distant metastasis (DM), progression free survival (PFS) and overall survival (OS) were analyzed by the Kaplan Meier method, concordance index and

SUBMITTER: Agrawal V 

PROVIDER: S-EPMC5398511 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature