Is antiplatelet treatment effective at attenuating the progression of white matter hyperintensities?

ABSTRACT:

Objective

We performed this study to assess the effect of an antiplatelet agent on the progression of white matter hyperintensities (WMH).

Methods

From August 2003 to May 2005, we consecutively enrolled patients who underwent brain magnetic resonance imaging (MRI) for health check-up purposes and showed no significant findings other than WMH of any degree. Patients were divided into two groups based on whether or not they received antiplatelet therapy. All patients had a follow-up brain MRI after 5 years and WMH volume change was measured using imaging analysis software. To minimize selection bias potentially arising from antiplatelet treatment assignment, analyses were inverse probability weighted.

Results

Among the 93 patients who met the inclusion criteria, 54 pati

SUBMITTER: Yoon CW 

PROVIDER: S-EPMC5398663 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature