A genetic risk score for CAD, psychological stress, and their interaction as predictors of CAD, fatal MI, non-fatal MI and cardiovascular death.

ABSTRACT:

Background

Psychological stress is an independent risk factor for cardiovascular disease (CVD), but the mechanism by which stress is associated with CVD is not entirely understood. Although genetic factors are implied in both stress responsivity and cardiovascular reactivity, no studies to date have investigated their interactions with stress for cardiovascular end points. The objective was to elucidate the association and interactions between a genetic risk score (GRS), individual genetic variants and stress for three cardiovascular end points: coronary artery disease (CAD), fatal myocardial infarction (MI), non-fatal MI, and cardiovascular death.

Methods and findings

18,559 participants from the Malmö Diet Cancer Study, a population-based prospective study, were included i

SUBMITTER: Svensson T 

PROVIDER: S-EPMC5398707 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature