Pulmonary vascular volume, impaired left ventricular filling and dyspnea: The MESA Lung Study.

ABSTRACT:

Background

Evaluation of impaired left ventricular (LV) filling has focused on intrinsic causes of LV dysfunction; however, pulmonary vascular changes may contribute to reduced LV filling and dyspnea. We hypothesized that lower total pulmonary vascular volume (TPVV) on computed tomography (CT) would be associated with dyspnea and decrements in LV end-diastolic volume, particularly among ever-smokers.

Methods

The Multi-Ethnic Study of Atherosclerosis recruited adults without clinical cardiovascular disease in 2000-02. In 2010-12, TPVV was ascertained as the volume of arteries and veins in the lungs detectable on non-contrast chest CT (vessels ≥1 mm diameter). Cardiac measures were assessed by magnetic resonance imaging (MRI). Dyspnea was self-reported.

Results

Of 2303

SUBMITTER: Aaron CP 

PROVIDER: S-EPMC5398710 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature