Brain Cancer Stem Cells in Adults and Children: Cell Biology and Therapeutic Implications.

ABSTRACT: Brain tumors represent some of the most malignant cancers in both children and adults. Current treatment options target the majority of tumor cells but do not adequately target self-renewing cancer stem cells (CSCs). CSCs have been reported to resist the most aggressive radiation and chemotherapies, and give rise to recurrent, treatment-resistant secondary malignancies. With advancing technologies, we now have a better understanding of the genetic, epigenetic and molecular signatures and microenvironmental influences which are useful in distinguishing between distinctly different tumor subtypes. As a result, efforts are now underway to identify and target CSCs within various tumor subtypes based on this foundation. This review discusses progress in CSC biology as it relates to targeted the

SUBMITTER: Abou-Antoun TJ 

PROVIDER: S-EPMC5398995 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature