Introducing Alternative-Based Thresholding for Defining Functional Regions of Interest in fMRI.

ABSTRACT: In fMRI research, one often aims to examine activation in specific functional regions of interest (fROIs). Current statistical methods tend to localize fROIs inconsistently, focusing on avoiding detection of false activation. Not missing true activation is however equally important in this context. In this study, we explored the potential of an alternative-based thresholding (ABT) procedure, where evidence against the null hypothesis of no effect and evidence against a prespecified alternative hypothesis is measured to control both false positives and false negatives directly. The procedure was validated in the context of localizer tasks on simulated brain images and using a real data set of 100 runs per subject. Voxels categorized as active with ABT can be confidently included in the defi

SUBMITTER: Degryse J 

PROVIDER: S-EPMC5399022 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature