Circadian rhythms of hemostatic factors in tetraplegia: a double-blind, randomized, placebo-controlled cross-over study of melatonin.

ABSTRACT:

Study design

This is a double-blind, randomized, placebo-controlled cross-over study of melatonin in complete tetraplegia.

Objectives

Tetraplegic patients have an increased risk of venous thrombosis despite prophylaxis, blunted variations in melatonin and altered circadian variation of several hemostatic markers. To examine whether melatonin could modify the regulation of hemostasis, we measured plasma melatonin and several markers of hemostasis in tetraplegic subjects with or without melatonin supplement.

Setting

The study was conducted in the Section for Spinal Cord Injury, Sunnaas Hospital, Nesoddtangen, Norway.

Methods

Six subjects with long-standing complete tetraplegia were included in this cross-over study with 2 mg of melatonin or placebo given 4 days b

SUBMITTER: Kostovski E 

PROVIDER: S-EPMC5399146 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature