Lack of interleukin-13 receptor α1 delays the loss of dopaminergic neurons during chronic stress.

ABSTRACT:

Background

The majority of Parkinson's disease (PD) cases are sporadic and idiopathic suggesting that this neurodegenerative disorder is the result of both environmental and genetic factors. Stress and neuroinflammation are among the factors being investigated for their possible contributions to PD. Experiments in rodents showed that severe chronic stress can reduce the number of dopaminergic neurons in the substantia nigra pars compacta (SNc); the same cells that are lost in PD. These actions are at least in part mediated by increased oxidative stress. Here, we tested the hypothesis that the interleukin-13 receptor alpha 1 (IL-13Rα1), a cytokine receptor whose activation increases the vulnerability of dopaminergic neurons to oxidative damage, participates in the stress-dependent d

SUBMITTER: Mori S 

PROVIDER: S-EPMC5399344 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature