Sirtuins in the phylum Basidiomycota: A role in virulence in Cryptococcus neoformans.

ABSTRACT: Virulence of Cryptococcus neoformans is regulated by a range of transcription factors, and is also influenced by the acquisition of adaptive mutations during infection. Beyond the temporal regulation of virulence factor production by transcription factors and these permanent microevolutionary changes, heritable epigenetic modifications such as histone deacetylation may also play a role during infection. Here we describe the first comprehensive analysis of the sirtuin class of NAD+ dependent histone deacetylases in the phylum Basidiomycota, identifying five sirtuins encoded in the C. neoformans genome. Each sirtuin gene was deleted and a wide range of phenotypic tests performed to gain insight into the potential roles they play. Given the pleiotropic nature of sirtuins in other species, it

SUBMITTER: Arras SDM 

PROVIDER: S-EPMC5399365 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature