Cross-disorder comparative analysis of comorbid conditions reveals novel autism candidate genes.

ABSTRACT:

Background

Numerous studies have highlighted the elevated degree of comorbidity associated with autism spectrum disorder (ASD). These comorbid conditions may add further impairments to individuals with autism and are substantially more prevalent compared to neurotypical populations. These high rates of comorbidity are not surprising taking into account the overlap of symptoms that ASD shares with other pathologies. From a research perspective, this suggests common molecular mechanisms involved in these conditions. Therefore, identifying crucial genes in the overlap between ASD and these comorbid disorders may help unravel the common biological processes involved and, ultimately, shed some light in the understanding of autism etiology.

Results

In this work, we used a two-fold

SUBMITTER: Diaz-Beltran L 

PROVIDER: S-EPMC5399393 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature