Canine β-defensin-1 (CBD1) gene as a possible marker for Leishmania infantum infection in dogs.

ABSTRACT:

Background

Canine leishmaniasis caused by Leishmania infantum is a parasitic disease of great veterinary significance. Some dogs infected by L. infantum may mount a strong cellular immune response and clear the infection, while others may respond with exaggerated antibody production against the parasite and develop an overt disease, which may be fatal, if left untreated. The initial factors triggering the polarization of the immune response towards a predominantly T-helper 1 or T-helper 2 cytokines, as well as the markers of resistance and susceptibility to L. infantum infection and disease development in dogs, are not fully understood. Herein, we assessed the association between single nucleotide polymorphisms (SNPs) in the canine β-defensin-1 (CBD1) gene and the infection by L. i

SUBMITTER: da Silva LG 

PROVIDER: S-EPMC5399410 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature