OnabotulinumtoxinA vs Sacral Neuromodulation on Refractory Urgency Urinary Incontinence in Women: A Randomized Clinical Trial.

ABSTRACT:

Importance

Women with refractory urgency urinary incontinence are treated with sacral neuromodulation and onabotulinumtoxinA with limited comparative information.

Objective

To assess whether onabotulinumtoxinA is superior to sacral neuromodulation in controlling refractory episodes of urgency urinary incontinence.

Design, setting, and participants

Multicenter open-label randomized trial (February 2012-January 2015) at 9 US medical centers involving 381 women with refractory urgency urinary incontinence.

Interventions

Cystoscopic intradetrusor injection of 200 U of onabotulinumtoxinA (n = 192) or sacral neuromodulation (n = 189).

Main outcomes and measures

Primary outcome, change from baseline mean number of daily urgency urinary incontinence episodes ove

SUBMITTER: Amundsen CL 

PROVIDER: S-EPMC5399419 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature