Pan genome and CRISPR analyses of the bacterial fish pathogen Moritella viscosa.

ABSTRACT:

Background

Winter-ulcer Moritella viscosa infections continue to be a significant burden in Atlantic salmon (Salmo salar L.) farming. M. viscosa comprises two main clusters that differ in genetic variation and phenotypes including virulence. Horizontal gene transfer through acquisition and loss of mobile genetic elements (MGEs) is a major driving force of bacterial diversification. To gain insight into genomic traits that could affect sublineage evolution within this bacterium we examined the genome sequences of twelve M. viscosa strains. Matches between M. viscosa clustered, regularly interspaced, short palindromic, repeats and associated cas genes (CRISPR-Cas) were analysed to correlate CRISPR-Cas with adaptive immunity against MGEs.

Results

The comparative genomic analysi

SUBMITTER: Karlsen C 

PROVIDER: S-EPMC5399434 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature