Effect of Dehydroepiandrosterone and Testosterone Supplementation on Systemic Lipolysis.

ABSTRACT:

Context

Dehydroepiandrosterone (DHEA) and T hormones are advertised as antiaging, antiobesity products. However, the evidence that these hormones have beneficial effects on adipose tissue metabolism is limited.

Objective

The objective of the study was to determine the effect of DHEA and T supplementation on systemic lipolysis during a mixed-meal tolerance test (MMTT) and an iv glucose tolerance test (IVGTT).

Design

This was a 2-year randomized, double-blind, placebo-controlled trial.

Setting

The study was conducted at a general clinical research center.

Participants

Sixty elderly women with low DHEA concentrations and 92 elderly men with low DHEA and bioavailable T concentrations participated in the study.

Interventions

Elderly women received 50 m

SUBMITTER: Espinosa De Ycaza AE 

PROVIDER: S-EPMC5399517 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature