Hypertension, cerebrovascular impairment, and cognitive decline in aged AβPP/PS1 mice.

ABSTRACT: Cardiovascular risk factors, especially hypertension, are also major risk factors for Alzheimer's disease (AD). To elucidate the underlying vascular origin of neurodegenerative processes in AD, we investigated the relation between systolic blood pressure (SBP) cerebral blood flow (CBF) and vasoreactivity with brain structure and function in a 16-18 months old double transgenic AβPP_swe/PS1_dE9 (AβPP/PS1) mouse model for AD. These aging AβPP/PS1 mice showed an increased SBP linked to a declined regional CBF. Furthermore, using advanced MRI techniques, decline of functional and structural connectivity was revealed in the AD-like mice coupled to impaired cognition, increased locomotor activity, and anxiety-related behavior. Post mortem analyses demonstrated also increased

SUBMITTER: Wiesmann M 

PROVIDER: S-EPMC5399593 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature