Inflammatory Markers and Risk for Cognitive Decline in Chronic Kidney Disease: The CRIC Study.

ABSTRACT:

Introduction

Chronic kidney disease (CKD) is associated with an increased risk of cognitive decline, but the mechanisms remain poorly defined. We sought to determine the relation between serum inflammatory markers and risk of cognitive decline among adults with CKD.

Methods

We studied 757 adults aged ≥55 years with CKD participating in the Chronic Renal Insufficiency Cohort Cognitive study. We measured interleukin (IL)-1β, IL-1 receptor antagonist, IL-6, tumor necrosis factor (TNF)-α, high-sensitivity C-reactive protein (hs-CRP), and fibrinogen in baseline plasma samples. We assessed cognitive function at regular intervals in 4 domains and defined incident impairment as a follow-up score more than 1 SD poorer than the group mean.

Results

The mean age of the sample was

SUBMITTER: Kurella Tamura M 

PROVIDER: S-EPMC5399682 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature