Sarcopenia, obesity, and mortality in US adults with and without chronic kidney disease.

ABSTRACT:

Introduction

In pre-dialysis chronic kidney disease (CKD), the association of muscle mass with mortality is poorly defined, and no study has examined outcomes related to the co-occurrence of low muscle mass and excess adiposity (sarcopenic-obesity). Methods: We examined abnormalities of muscle and fat mass in adult participants of the National Health and Nutrition Examination Survey 1999-2004. We determined whether associations of body composition with all-cause mortality differed between participants with CKD compared to those without.

Results

CKD modified the association of body composition with mortality (p=0.01 for interaction). In participants without CKD, both sarcopenia and sarcopenic obesity were independently associated with increased mortality compared with normal

SUBMITTER: Androga L 

PROVIDER: S-EPMC5399775 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature