The centriolar satellite protein CCDC66 interacts with CEP290 and functions in cilium formation and trafficking.

ABSTRACT: Centriolar satellites are membrane-less structures that localize and move around the centrosome and cilium complex in a microtubule-dependent manner. They play important roles in centrosome- and cilium-related processes, including protein trafficking to the centrosome and cilium complex, and ciliogenesis, and they are implicated in ciliopathies. Despite the important regulatory roles of centriolar satellites in the assembly and function of the centrosome and cilium complex, the molecular mechanisms of their functions remain poorly understood. To dissect the mechanism for their regulatory roles during ciliogenesis, we performed an analysis to determine the proteins that localize in close proximity to the satellite protein CEP72, among which was the retinal degeneration gene product CCDC66.

SUBMITTER: Conkar D 

PROVIDER: S-EPMC5399785 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature