Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung.

ABSTRACT:

Background

Aldehyde dehydrogenases (ALDHs) play a major role in detoxification of aldehydes. High expression of ALDHs is a marker for stem cells of many organs including the lungs. A common polymorphism in ALDH2 gene (ALDH2*2) results in inactivation of the enzyme and is associated with alcohol flushing syndrome and increased risk for cardiovascular and Alzheimer's diseases and some cancers. The effect of this ALDH2 polymorphism on the lung and its stem cells has not been thoroughly examined.

Methods

We examined the association between the ALDH2*2 allele and lung function parameters in a population of healthy individuals. We also examined its association with the incidence of asthma and COPD in patient cohorts. We used the in vitro colony forming assay to detect the effect o

SUBMITTER: Kuroda A 

PROVIDER: S-EPMC5399815 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature