Iron-regulated small RNA expression as Neisseria gonorrhoeae FA 1090 transitions into stationary phase growth.

ABSTRACT:

Background

For most pathogens, iron (Fe) homeostasis is crucial for maintenance within the host and the ability to cause disease. The primary transcriptional regulator that controls intracellular Fe levels is the Fur (ferric uptake regulator) protein, which exerts its action on transcription by binding to a promoter-proximal sequence termed the Fur box. Fur-regulated transcriptional responses are often fine-tuned at the post-transcriptional level through the action of small regulatory RNAs (sRNAs). Consequently, identifying sRNAs contributing to the control of Fe homeostasis is important for understanding the Fur-controlled bacterial Fe-response network.

Results

In this study, we sequenced size-selected directional libraries representing sRNA samples from Neisseria gonorrhoe

SUBMITTER: Jackson LA 

PROVIDER: S-EPMC5399841 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature