Metformin ameliorates insulitis in STZ-induced diabetic mice.

ABSTRACT:

Background & aims

Metformin is currently the most widely used first-line hypoglycemic agent for diabetes mellitus. Besides glucose-lowering action, there is increasingly interest in the potential anti-inflammatory action of this drug. In the present study, we investigated the actions of metformin on experimental insulitis using STZ-induced diabetic mice.

Methods

Mice with acute diabetes induced by STZ were administered metformin by gavage. Changes of blood glucose and body weight, and the daily amount of food and water intake were measured. Pancreatic tissues were collected for histologic analyses. Pathological assessment and immunohistochemistry analysis were used to determine the effect of metformin on insulitis. Inflammatory cytokines in the pancreas and insulin levels we

SUBMITTER: Han X 

PROVIDER: S-EPMC5399881 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature