Transmission patterns and evolution of respiratory syncytial virus in a community outbreak identified by genomic analysis.

ABSTRACT: Detailed information on the source, spread and evolution of respiratory syncytial virus (RSV) during seasonal community outbreaks remains sparse. Molecular analyses of attachment (G) gene sequences from hospitalized cases suggest that multiple genotypes and variants co-circulate during epidemics and that RSV persistence over successive seasons is characterized by replacement and multiple new introductions of variants. No studies have defined the patterns of introduction, spread and evolution of RSV at the local community and household level. We present a whole genome sequence analysis of 131 RSV group A viruses collected during 6-month household-based RSV infection surveillance in Coastal Kenya, 2010 within an area of 12 km². RSV infections were identified by regular symptom-ind

SUBMITTER: Agoti CN 

PROVIDER: S-EPMC5399923 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature