Sequence-based taxonomic framework for the classification of uncultured single-stranded DNA viruses of the family Genomoviridae.

ABSTRACT: With the advent of metagenomics approaches, a large diversity of known and unknown viruses has been identified in various types of environmental, plant, and animal samples. One such widespread virus group is the recently established family Genomoviridae which includes viruses with small (∼2-2.4 kb), circular ssDNA genomes encoding rolling-circle replication initiation proteins (Rep) and unique capsid proteins. Here, we propose a sequence-based taxonomic framework for classification of 121 new virus genomes within this family. Genomoviruses display ∼47% sequence diversity, which is very similar to that within the well-established and extensively studied family Geminiviridae (46% diversity). Based on our analysis, we establish a 78% genome-wide pairwise identity as a species de

SUBMITTER: Varsani A 

PROVIDER: S-EPMC5399927 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature