Diabetes Mellitus and Latent Tuberculosis Infection: A Systematic Review and Metaanalysis.

ABSTRACT:

Background

Despite the well-documented association between diabetes and active tuberculosis, evidence of the association between diabetes and latent tuberculosis infection (LTBI) remains limited and inconsistent.

Methods

We included observational studies that applied either the tuberculin skin test or the interferon gamma release assay for diagnosis of LTBI and that provided adjusted effect estimate for the association between diabetes and LTBI. We searched PubMed and EMBASE through 31 January 2016. The risk of bias of included studies was assessed using a quality assessment tool modified from the Newcastle-Ottawa scale.

Results

Thirteen studies (1 cohort study and 12 cross-sectional studies) were included, involving 38263 participants. The cohort study revealed an in

SUBMITTER: Lee MR 

PROVIDER: S-EPMC5399944 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature