Dynamics of Cough Frequency in Adults Undergoing Treatment for Pulmonary Tuberculosis.

ABSTRACT:

Background

Cough is the major determinant of tuberculosis transmission. Despite this, there is a paucity of information regarding characteristics of cough frequency throughout the day and in response to tuberculosis therapy. Here we evaluate the circadian cycle of cough, cough frequency risk factors, and the impact of appropriate treatment on cough and bacillary load.

Methods

We prospectively evaluated human immunodeficiency virus-negative adults (n = 64) with a new diagnosis of culture-proven, drug-susceptible pulmonary tuberculosis immediately prior to treatment and repeatedly until treatment day 62. At each time point, participant cough was recorded (n = 670) and analyzed using the Cayetano Cough Monitor. Consecutive coughs at least 2 seconds apart were counted as separat

SUBMITTER: Proano A 

PROVIDER: S-EPMC5399950 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature