Genome-wide interactions between FSH and insulin-like growth factors in the regulation of human granulosa cell differentiation.

ABSTRACT:

Study question

Is the genome-wide response of human cumulus cells to FSH and insulin-like growth factors (IGFs) comparable to the response observed in undifferentiated granulosa cells (GCs)?

Summary answer

FSH actions in human cumulus cells mimic those observed in preantral undifferentiated GCs from laboratory animals, and approximately half of the regulated genes are dependent on the simultaneous activation of the IGF1 receptor (IGF1R).

What is known already

Animal studies have shown that FSH and the IGFs system are required for follicle growth and maturation. In humans, IGF levels in the follicular fluid correlate with patients' responses to IVF protocols. The main targets of FSH and IGFs in the ovary are the GCs; however, the genomic mechanisms involved in the resp

SUBMITTER: Stocco C 

PROVIDER: S-EPMC5400056 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature