Levels of trophectoderm mitochondrial DNA do not predict the reproductive potential of sibling embryos.

ABSTRACT:

Study question

What is the predictive value of trophectoderm mitochondrial DNA (mtDNA) quantity for blastocyst reproductive potential?

Summary answer

This study demonstrates that, within a given cohort, mtDNA quantitation does not distinguish between embryos that implant and embryos that do not implant after double embryo transfer (DET).

What is already known

An association between implantation failure and increased quantities of mtDNA has been observed in two studies but not in a third.

Study design, size and duration

A total of 187 patients (nine who received donor oocytes) with DET of one male and one female euploid blastocyst were included in this retrospective study, with 69 singleton deliveries providing the primary dataset to evaluate the predictive valu

SUBMITTER: Treff NR 

PROVIDER: S-EPMC5400072 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature