Staphylococcus aureus CC395 harbours a novel composite staphylococcal cassette chromosome mec element.

ABSTRACT:

Background

CoNS species are likely reservoirs of the staphylococcal cassette chromosome mec (SCC mec ) in Staphylococcus aureus . S . aureus CC395 is unique as it is capable of exchanging DNA with CoNS via bacteriophages, which are also known to mediate transfer of SCC mec .

Objectives

To analyse the structure and putative origin of the SCC mec element in S . aureus CC395.

Methods

The only MRSA CC395 strain described in the literature, JS395, was subjected to WGS, and its SCC mec element was compared with those found in CoNS species and other S. aureus strains.

Results

JS395 was found to carry an unusually large 88 kb composite SCC mec element. The 33 kb region downstream of orfX harboured a type V SCC mec element and a CRISPR locus, which was most similar to t

SUBMITTER: Larsen J 

PROVIDER: S-EPMC5400086 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature