Comparative genomics of Burkholderia multivorans, a ubiquitous pathogen with a highly conserved genomic structure.

ABSTRACT: The natural environment serves as a reservoir of opportunistic pathogens. A well-established method for studying the epidemiology of such opportunists is multilocus sequence typing, which in many cases has defined strains predisposed to causing infection. Burkholderia multivorans is an important pathogen in people with cystic fibrosis (CF) and its epidemiology suggests that strains are acquired from non-human sources such as the natural environment. This raises the central question of whether the isolation source (CF or environment) or the multilocus sequence type (ST) of B. multivorans better predicts their genomic content and functionality. We identified four pairs of B. multivorans isolates, representing distinct STs and consisting of one CF and one environmental isolate each. All genom

SUBMITTER: Peeters C 

PROVIDER: S-EPMC5400248 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature