Chemical Reaction Network Theory elucidates sources of multistability in interferon signaling.

ABSTRACT: Bistability has important implications in signaling pathways, since it indicates a potential cell decision between alternative outcomes. We present two approaches developed in the framework of the Chemical Reaction Network Theory for easy and efficient search of multiple steady state behavior in signaling networks (both with and without mass conservation), and apply them to search for sources of bistability at different levels of the interferon signaling pathway. Different type I interferon subtypes and/or doses are known to elicit differential bioactivities (ranging from antiviral, antiproliferative to immunomodulatory activities). How different signaling outcomes can be generated through the same receptor and activating the same JAK/STAT pathway is still an open question. Here, we detect

SUBMITTER: Otero-Muras I 

PROVIDER: S-EPMC5400276 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature