Dose-response relationships for environmentally mediated infectious disease transmission models.

ABSTRACT: Environmentally mediated infectious disease transmission models provide a mechanistic approach to examining environmental interventions for outbreaks, such as water treatment or surface decontamination. The shift from the classical SIR framework to one incorporating the environment requires codifying the relationship between exposure to environmental pathogens and infection, i.e. the dose-response relationship. Much of the work characterizing the functional forms of dose-response relationships has used statistical fit to experimental data. However, there has been little research examining the consequences of the choice of functional form in the context of transmission dynamics. To this end, we identify four properties of dose-response functions that should be considered when selecting a fu

SUBMITTER: Brouwer AF 

PROVIDER: S-EPMC5400279 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature