HOPPSIGEN: a database of human and mouse processed pseudogenes.

ABSTRACT: Processed pseudogenes result from reverse transcribed mRNAs. In general, because processed pseudogenes lack promoters, they are no longer functional from the moment they are inserted into the genome. Subsequently, they freely accumulate substitutions, insertions and deletions. Moreover, the ancestral structure of processed pseudogenes could be easily inferred using the sequence of their functional homologous genes. Owing to these characteristics, processed pseudogenes represent good neutral markers for studying genome evolution. Recently, there is an increasing interest for these markers, particularly to help gene prediction in the field of genome annotation, functional genomics and genome evolution analysis (patterns of substitution). For these reasons, we have developed a method to annot

SUBMITTER: Khelifi A 

PROVIDER: S-EPMC540038 | biostudies-literature | 2005 Jan

REPOSITORIES: biostudies-literature