Diabetic concentrations of metformin inhibit platelet-mediated ovarian cancer cell progression.

ABSTRACT: Clinical studies have suggested a survival benefit in ovarian cancer patients with type 2 diabetes mellitus taking metformin, however the mechanism by which diabetic concentrations of metformin could deliver this effect is still poorly understood. Platelets not only represent an important reservoir of growth factors and angiogenic regulators, they are also known to participate in the tumor microenvironment implicated in tumor growth and dissemination. Herein, we investigated if diabetic concentrations of metformin could impinge upon the previously reported observation that platelet induces an increase in the tube forming capacity of endothelial cells (angiogenesis) and upon ovarian cancer cell aggressiveness. We demonstrate that metformin inhibits the increase in angiogenesis brought about

SUBMITTER: Erices R 

PROVIDER: S-EPMC5400552 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature