PET imaging of α₇ nicotinic acetylcholine receptors: a comparative study of [¹⁸F]ASEM and [¹⁸F]DBT-10 in nonhuman primates, and further evaluation of [¹⁸F]ASEM in humans.

ABSTRACT:

Purpose

The α₇ nicotinic acetylcholine receptor (nAChR) is implicated in many neuropsychiatric disorders, making it an important target for positron emission tomography (PET) imaging. The first aim of this work was to compare two α₇ nAChRs PET radioligands, [¹⁸F]ASEM (3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6-([¹⁸F]fluorodibenzo[b,d]thiophene 5,5-dioxide) and [¹⁸F]DBT-10 (7-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-2-([¹⁸F]fluorodibenzo[b,d]thiophene 5,5-dioxide), in nonhuman primates. The second aim was to assess further the quantification and test-retest variability of [¹⁸F]ASEM in humans.

Methods

PET scans with high specific activity [¹⁸F]ASEM or [¹⁸F]DBT-10 were acquired in three r

SUBMITTER: Hillmer AT 

PROVIDER: S-EPMC5400702 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature