Alterations in microRNA expression associated with alcohol consumption in rectal cancer subjects.

ABSTRACT:

Purpose

Alcohol consumption has been purported to influence many diseases. MicroRNAs (miRNAs) may be influenced by compounds found in alcohol. In this investigation, we test the hypothesis that total alcohol, beer, wine, and hard liquor influence miRNA expression.

Methods

We studied 1447 colorectal (CR) cancer cases with normal CR mucosa and carcinoma miRNA expression data along with alcohol consumption data. We analyzed long-term and long-term and current (LTC) alcohol use for beer, liquor, and wine with miRNA expression between paired carcinoma and normal colon and rectal tissues, adjusting for multiple comparisons using the positive false discovery rate q-value. MiRNAs associated significantly with alcohol were examined with all-cause mortality (ACM). MiRNAs associated si

SUBMITTER: Mullany LE 

PROVIDER: S-EPMC5400787 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature