Chlamydia trachomatis Cellular Exit Alters Interactions with Host Dendritic Cells.

ABSTRACT: The strategies utilized by pathogens to exit host cells are an area of pathogenesis which has received surprisingly little attention, considering the necessity of this step for infections to propagate. Even less is known about how exit through these pathways affects downstream host-pathogen interactions and the generation of an immune response. Chlamydia trachomatis exits host epithelial cells through two equally active mechanisms: lysis and extrusion. Studies have characterized the outcome of interactions between host innate immune cells, such as dendritic cells and macrophages, and free, extracellular Chlamydia bacteria, such as those resulting from lysis. Exit via extrusion generates a distinct, host-membrane-bound compartment of Chlamydia separate from the original infected cell. In th

SUBMITTER: Sherrid AM 

PROVIDER: S-EPMC5400845 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature