Membrane-enriched proteome changes and prion protein expression during neural differentiation and in neuroblastoma cells.

ABSTRACT:

Background

The function of the prion protein, involved in the so-called prion diseases, remains a subject of intense debate and the possibility that it works as a pleiotropic protein through the interaction with multiple membrane proteins is somehow supported by recent reports. Therefore, the use of proteomic and bioinformatics combined to uncover cellular processes occurring together with changes in the expression of the prion protein may provide further insight into the putative pleiotropic role of the prion protein.

Results

This study assessed the membrane-enriched proteome changes accompanying alterations in the expression of the prion protein. A 2D-DIGE approach was applied to two cell lines after prefractionation towards the membrane protein subset: an embryonic stem c

SUBMITTER: Macedo JA 

PROVIDER: S-EPMC5401558 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature