Outcomes after diagnosis of mild cognitive impairment in a large autopsy series.

ABSTRACT:

Objective

To determine clinical and neuropathological outcomes following a clinical diagnosis of mild cognitive impairment (MCI).

Methods

Data were drawn from a large autopsy series (N = 1,337) of individuals followed longitudinally from normal or MCI status to death, derived from 4 Alzheimer Disease (AD) Centers in the United States.

Results

Mean follow-up was 7.9 years. Of the 874 individuals ever diagnosed with MCI, final clinical diagnoses were varied: 39.2% died with an MCI diagnosis, 46.8% with a dementia diagnosis, and 13.9% with a diagnosis of intact cognition. The latter group had pathological features resembling those with a final clinical diagnosis of MCI. In terms of non-AD pathologies, both primary age-related tauopathy (p < 0.05) and brain arterioloscler

SUBMITTER: Abner EL 

PROVIDER: S-EPMC5401633 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature