Language functional MRI and direct cortical stimulation in epilepsy preoperative planning.

ABSTRACT:

Objective

Presurgical language assessment can help minimize damage to eloquent cortex during resective epilepsy surgery. Two methods for presurgical language mapping are functional MRI (fMRI) and direct cortical stimulation (DCS) of implanted subdural electrodes. We compared fMRI results to DCS to help optimize noninvasive language localization and assess its validity.

Methods

We studied 19 patients referred for presurgical evaluation of drug-resistant epilepsy. Patients completed four language tasks during preoperative fMRI. After subdural electrode implantation, we used DCS to localize language areas. For each stimulation site, we determined whether language positive electrode pairs intersected with significant fMRI activity clusters for language tasks.

Results

Sens

SUBMITTER: Austermuehle A 

PROVIDER: S-EPMC5401636 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature