Chromosome 1 Sequence Analysis of C57BL/6J-Chr1^KM Mouse Strain.

ABSTRACT: The Chinese Kunming (KM) mouse is a widely used outbred mouse stock in China. However, its genetic structure remains unclear. In this study, we sequenced the genome of the C57BL/6J-Chr1^KM (B6-Chr1^KM) strain, the chromosome 1 (Chr 1) of which was derived from one KM mouse. With 36.6× average coverage of the entire genome, 0.48 million single nucleotide polymorphisms (SNPs) and 96,679 indels were detected on Chr 1 through comparison with reference strain C57BL/6J. Moreover, 46,590 of them were classified as novel mutations. Further functional annotation identified 155 genes harboring potentially functional variants, among which 27 genes have been associated with human diseases. We then performed sequence similarity and Bayesian concordance analysis using the SNPs identi

SUBMITTER: Xu F 

PROVIDER: S-EPMC5401761 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature