Clear Cell Type A and B Molecular Subtypes in Metastatic Clear Cell Renal Cell Carcinoma: Tumor Heterogeneity and Aggressiveness.

ABSTRACT:

Background

Intratumor molecular heterogeneity has been reported for primary clear cell renal cell carcinoma (ccRCC) tumors; however, heterogeneity in metastatic ccRCC tumors has not been explored.

Objective

To evaluate intra- and intertumor molecular heterogeneity in resected metastatic ccRCC tumors.

Design, setting, and participants

We identified 111 patients who had tissue available from their primary tumor and at least one metastasis. ClearCode34 genes were analyzed for all tumors.

Outcome measurements and statistical analysis

Primary and metastatic tumors were classified as clear cell type A (ccA) or B (ccB) subtypes. Logistic and Cox regression were used to evaluate associations with pathologic features and survival.

Results and limitations

Intratum

SUBMITTER: Serie DJ 

PROVIDER: S-EPMC5401797 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature