Changes in muscle fiber contractility and extracellular matrix production during skeletal muscle hypertrophy.

ABSTRACT: Skeletal muscle can adapt to increased mechanical loads by undergoing hypertrophy. Transient reductions in whole muscle force production have been reported during the onset of hypertrophy, but contractile changes in individual muscle fibers have not been previously studied. Additionally, the extracellular matrix (ECM) stores and transmits forces from muscle fibers to tendons and bones, and determining how the ECM changes during hypertrophy is important in understanding the adaptation of muscle tissue to mechanical loading. Using the synergist ablation model, we sought to measure changes in muscle fiber contractility, collagen content, and cross-linking, and in the expression of several genes and activation of signaling proteins that regulate critical components of myogenesis and ECM synthe

SUBMITTER: Mendias CL 

PROVIDER: S-EPMC5401954 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature