Human fetal heart specific coexpression network involves congenital heart disease/defect candidate genes.

ABSTRACT: Heart development is a complex process requiring dynamic transcriptional regulation. Disturbance of this process will lead to severe developmental defects such as congenital heart disease/defect (CHD). CHD is a group of complex disorder with high genetic heterogeneity, common pathways associated with CHD remains largely unknown. In the manuscript, we focused on the tissue specific genes in human fetal heart samples to explore such pathways. We used the RNA microarray dataset of human fetal tissues from ENCODE project to identify genes with heart tissue specific expression. A transcriptional network was constructed for these genes based on the Pearson correlation coefficients of their expression levels. Function, selective constraints and disease associations of these genes were then examin

SUBMITTER: Wang B 

PROVIDER: S-EPMC5402266 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature